2015 Publications

• Alexander BT. The Impact of Nutritional Insults during Fetal Life on Blood Pressure. J Nutr Sci Vitaminol (Tokyo). 2015; 61 Supplement:S5-S6. PMID: 26598884.
• Alexander BT, Dasinger JH, Intapad S. Fetal programming and cardiovascular pathology. Compr Physiol. 2015; 5:997-1025. PMCID: PMC4772789.
• Bassi M, Nakamura NB, Furuya WI, Colombari DS, Menani JV, do Carmo JM, da Silva AA, Hall JE, Colombari E. Activation of the brain melanocortin system is required for leptin-induced modulation of chemorespiratory function. Acta Physiol (Oxf). 2015; 213:893-901. PMCID: PMC4362918.
• Bassi M, Werner IF, Zoccal DB, Menani JV, Columbari E, Hall JE, da Silva AA, do Carmo JM, Columbari DSA. Control of respiratory and cardiovascular functions by leptin. Life Sci. 2015; 125:25-31. PMCID: PMC4355938.
• Chade AR, Tullos N, Stewart NJ, Surles B. Endothelin-a receptor antagonism after renal angioplasty enhances renal recovery in renovascular disease. J Am Soc Nephrol. 2015; 26:1071-1080. PMCID: PMC4413765.
• Correa WG, Durand MT, Becari C, Tezini GC, do Carmo JM, de Oliveira M, Prado CM, Fazan R Jr, Salgado HC. Pyridostigmine prevents haemodynamic alterations but does not affect their nycthemeral oscillations in infarcted mice. Auton Neurosci. 2015 Jan;187:50-5. PMID: 25434306.
• da Silva AA, do Carmo JM, Dubinion JH, Bassi M, Mokhtarpouriani K, Hamza SM, Hall JE. Chronic central nervous system MC3/4R blockade attenuates hypertension induced by nitric oxide synthase inhibition but not by angiotensin II infusion. Hypertension. 2015; 65:171-177. PMCID: PMC4267912.
• da Silva AA, do Carmo JM, Wang Z, Hall JE. Leptin, autonomic nervous system, and hypertension. Leptin: Regulation and Clinical Applications. Ed. Sam Dagogo-Jack. Springer, 2015. Pg 175-188.
• da Silva AA, Spradley FT, Granger JP, Hall JE, do Carmo JM. Brain-mediated antidiabetic, anorexic, and cardiovascular actions of leptin require melanocortin-4 receptor signaling. J Neurophysiol. 2015; 113:2786-2791. PMCID: PMC4416609.
• DeCoux A, Tian Y, DeLeon-Pennell KY, Nguyen NT, de Castro Brás LE, Flynn ER, Cannon PL, Griswold ME, Jin YF, Puskarich MA, Jones AE, Lindsey ML. Plasma glycoproteomics reveals sepsis outcomes linked to distinct proteins in common pathways. Crit Care Med. 2015; 43:2049-2058. PMCID: PMC4573827.
• DeLeon-Pennell KY, Altara R, Yabluchanskiy A, Modesti A, Lindsey ML. The circular relationship between matrix metalloproteinase-9 and inflammation following myocardial infarction. IUBMB Life. 2015; 67:611-618. PMCID: PMC4553095.
• DeLeon-Pennell KY, Lindsey ML. Cardiac aging: Send in the vinculin reinforcements. Sci Transl Med. 2015; 7:292fs26. PMID: 26084802.
• deShazo RD, Hall JE, Skipworth LB. Obesity bias, medical technology, and the hormonal hypothesis: should we stop demonizing fat people? Am J Med. 2015 May;128(5):456-60. PMID: 25534419.
• do Carmo JM, da Silva AA, Hall JE. Role of hindbrain melanocortin-4 receptor activity in controlling cardiovascular and metabolic functions in spontaneously hypertensive rats. J Hypertens. 2015; 33:1201-1206. PMCID: PMC4748968.
• Drummond HA. Nontubular epithelial Na+ channel proteins in cardiovascular regulation. Physiol Rep. 2015; 3. PMCID: PMC4463832.
• Drummond HA, Stec DE. βENaC acts as a mechanosensor in renal vascular smooth muscle cells that contributes to renal myogenic blood flow regulation, protection from renal injury and hypertension. J Nephrol Res. 2015; 1:1-9. PMCID: PMC5138029.
• Fan F, Chen CC, Zhang J, Schreck CM, Roman EA, Williams JM, Hirata T, Sharma M, Beard DA, Savin VJ, Roman RJ. Fluorescence dilution technique for measurement of albumin reflection coefficient in isolated glomeruli. Am J Physiol Renal Physiol. 2015; 309:F1049-F1059. PMCID: PMC4683305.
• Fan F, Geurts AM, Murphy SR, Pabbidi MR, Jacob HJ, Roman RJ. Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat. Am J Physiol Regul Integr Comp Physiol. 2015; 308:R379-R390. PMCID: PMC4346760.
• Fan F, Muroya Y, Roman RJ. Cytochrome P450 eicosanoids in hypertension and renal disease. Curr Opin Nephrol Hypertens. 2015; 24:37-46. PMCID: PMC4260681.
• Gannon KP, McKey SE, Stec DE, Drummond HA. Altered myogenic vasoconstriction and regulation of whole kidney blood flow in the ASIC2 knockout mouse. Am J Physiol Renal Physiol. 2015; 308:F339-F348. PMCID: PMC4329487.
• George EM, Granger JP. Potential therapeutic value of the heme oxygenase system in preeclampsia. Pregnancy Hypertens. 2015 Jan;5(1):139.
• George EM, Liu H, Robinson GG, Mahdi F, Perkins E, Bidwell GL 3rd. Growth factor purification and delivery systems (PADS) for therapeutic angiogenesis. Vasc Cell. 2015; 7:1. PMCID: PMC4316602.
• George EM, Stout JM, Stec DE, Granger JP.  Heme oxygenase induction attenuates TNF-α-induced hypertension in pregnant rodents. Front. Pharmacol. 2015; 6:165. PMCID: PMC4538306.
• Gillis EE, Williams JM, Garrett MR, Mooney JN, Sasser JM. The Dahl salt-sensitive rat is a spontaneous model of superimposed preeclampsia. Am J Physiol Regul Integr Comp Physiol. 2015; 309:R62-R70. PMCID: PMC4491533.
• Hall JE, do Carmo JM, da Silva AA, Wang Z, Hall ME.  Obesity-induced hypertension: interaction of neurohurmonal and renal mechanisms. Circulation Res. 2015; 116:991-1006. PMCID: PMC4363087.
• Hall ME, Harmancey R, Stec DE. Lean heart: role of leptin in cardiac hypertrophy and metabolism. World J Cardiol. 2015; 7:511-524. PMCID: PMC4577678.
• Hall ME, Yanes LL, Long RC, Koch CA. Hormones of the Cardiovascular System, in www.thyroidmanager.org, February 2, 2015, Published by ENDOCRINE EDUCATION Inc, South Dartmouth, MA 02748, February,2015. PMID: 25905321.
• Harmancey R, Haight DL, Watts KA, Taegtmeyer H. Chronic hyperinsulinemia causes selective insulin resistance and down-regulates uncoupling protein 3 (UCP3) through the activation of sterol regulatory element-binding protein (SREBP)-1 transcription factor in the mouse heart. J Biol Chem. 2015; 290:30947-30961. PMCID: PMC4692222.
• Henegar JR, Zhang Z, Hata C, Narciso I, Hall ME, Hall  JE. Catheter-based radiofrequency renal denervation: location effects on renal norepinephrine. Am J Hypertens. 2015; 28:909-914. PMCID: PMC4804121.
• Horton WB, Taylor JS, Ragland TJ, Subauste AR. Diabetic muscle infarction: A systematic review. BMJ Open Diabetes Res Care. 2015 Apr 24;3(1):e000082. PMCID: PMC4410119.
• Hosick PA, Alamodi AA, Hankins MW, Stec DE. Chronic treatment with a carbon monoxide releasing molecule reverses dietary induced obesity in mice. Adipocyte. 2015; 5:1-10. PMCID: PMC4836479.
• Hye Khan MA, Sharma A, Rarick KR, Roman RJ, Harder DR, Imig JD. Elevated Aminopeptidase P Attenuates Cerebral Arterial Responses to Bradykinin in Fawn-Hooded Hypertensive Rats. PLoS One.2015; 10:e0145335. PMCID: PMC4686180.
• Intapad S, Ojeda NB, Varney E, Royals TP, Alexander BT. Sex-specific effect of endothelin in the blood pressure response to acute angiotensin II in growth-restricted rats. Hypertension. 2015; 66:1260-1266. PMCID: PMC4656137.
• Iwano H, Kamimura D, Fox E, Hall M, Vlachos P, Little WC. Altered spatial distribution of the diastolic left ventricular pressure difference in heart failure. J Am Soc Echocardiogr. 2015; 28:597-605. PMCID: PMC5441386.
• Iyer RP, Jung M, Lindsey ML. Using the laws of thermodynamics to understand how matrix metalloproteinases coordinate the myocardial response to injury. Metalloproteinases Med. 2015; 2:75-82. PMCID: PMC4930103.
• Iyer RP, Patterson NL, Zouein FA, Ma Y, Dive V, de Castro Brás LE, Lindsey ML. Early matrix metalloproteinase-12 inhibition worsens post-myocardial infarction cardiac dysfunction by delaying inflammation resolution. Int J Cardiol. 2015; 185:198-208. PMCID: PMC4406852.
• Jia Z, Johnson AC, Wang X, Guo Z, Dreisbach AW, Lewin JR, Kyle PB, Garrett MR. Allelic Variants in Arhgef11 via the Rho-Rock Pathway Are Linked to Epithelial-Mesenchymal Transition and Contributes to Kidney Injury in the Dahl Salt-Sensitive Rat. PLoS One. 2015; 10:e0132553. PMCID: PMC4501567.
• Kojima N, Williams JM, Slaughter TN, Kato S, Takahashi T, Miyata N, Roman RJ. Renoprotective effects of combined SGLT2 and ACE inhibitor therapy in diabetic Dahl S rats. Physiol Rep. 2015; 3. PMCID: PMC4552522.
• Lindsey ML, Iyer RP, Zamilpa R, Yabluchanskiy A, DeLeon-Pennell KY, Hall ME, Zouein FA, Bratton D, Flynn ER, Cannon PL, Tian Y, Jin YF, Lange RA, Tokmina-Roszyk D, Fields GB, de Castro Brás LE. A novel collagen matricryptin reduces left ventricular dilation post-myocardial infarction by promoting scar formation and angiogenesis. J Am Coll Cardiol. 2015; 66:1364-1374. PMCID: PMC4575409.
• Lindsey ML, Yabluchanskiy A, Ma Y. Tissue inhibitor of metalloproteinase-1: actions beyond matrix metalloproteinase inhibition. Cardiology. 2015; 132:147-150. PMCID: PMC4734898.
• Lindsey ML, Zouein FA, Tian T, Padmanabhan IR, de Castro Brás LE. Osteopontin is proteolytically processed by matrix metalloproteinase 9. Can J Physiol Pharmacol. 2015; 93:879-886. PMCID: PMC4764993.
• Loprinzi PD, Hall ME. Physical activity and dietary behavior with red blood cell distribution width. Physiol Behav. 2015; 149:35-38. PMID: 26003494.
• Lu Y, Wei J, Stec DE, Roman RJ, Ge Y, Cheng L, Liu EY, Zhang J, Hansen PB, Fan F, Juncos LA, Wang L, Pollock J, Huang PL, Fu Y, Wang S, Liu R. Macula densa nitric oxide synthase 1β protects against salt-sensitive hypertension. J Am Soc. Nephrol. 2015; 27:2346-2356. PMCID: PMC4978040.
• Lu Y, Zhang R, Ge Y, Carlstrom M, Wang S, Fu Y, Cheng L, Wei J, Roman RJ, Wang L, Gao X, Liu R. Identification and function of adenosine A3 receptor in afferent arterioles. Am J Physiol Renal Physiol.2015; 308:F1020-F1025. PMCID: PMC4420990.
• Ma Y. Neuron-derived orphan receptor 1: working towards a common goal. J Mol Cell Cardiol. 2015; 80:98-100. PMID: 25575883.
• Ma Y, Chiao YA, Clark R, Flynn Er, Yabluchanskiy A, Ghasemi O, Zouein F, Lindsey ML, Jin YF. Deriving a cardiac ageing signature to reveal MMP-9-dependent inflammatory signaling in senescence. Cardiovasc Res. 2015; 106;421-431. PMCID: PMC4498140.
• Maranon R, Lima R, Spradley FT, do Carmo JM, Zhang H, Smith A, Bui BE, Thomas RL, Moulana M, Hall JE, Granger JP, Reckelhoff JF. Roles of the sympathetic nervous system, renal nerves, and CNS melanocortin-4 receptor in the elevated blood pressure in hyperandrogenemic female rats. Am J Physiol Regu Integr Comp Physiol. 2015; 308:R708-R713. PMCID: PMC4398855.
• McPherson K, Cornelius D, Thomas D, Taylor L, Spires D, Johnson A, Lamarca B, Garrett MR, Williams JM. Early development of glomerular injury in Dahl salt-sensitive rats with metabolic syndrome independent of diabetes and hypertension. FASEB J. 2015 April;29(1):964.8.
• Milks MW, Upadhya B, Hall ME, Vas S, Hundley WG, Stacey RB.  Right ventricular stress-induced perfusion defects and late gadolinium enhancement in coronary artery disease. J Comput Assist Tomogr.  2015; 39:185-188. PMID: 25423554.
• Mittwede PN, Bergin PF, Clemmer JS, Xiang L. Obesity, malnutrition, and the responses to critical illness. Crit Care Med. 2015; 43:e321. PMCID: PMC4507436.
• Mittwede PN, Xiang L, Lu S, Clemmer JS, Hester RL. Oxidative stress contributes to orthopedic trauma-induced acute kidney injury in obese rats. Am J Physiol Renal Physiol. 2015; 308:F157-F163.  PMCID: PMC4338927.
• Munusamy S, do Carmo JM, Hosler JP, Hall JE. Obesity-induced changes in kidney mitochondria and endoplasmic reticulum in the presence or absence of leptin. Am J Physiol Renal Physiol. 2015; 309:F731-F743. PMCID: PMC4609921.
• Muroya Y, Fan F, Regner KR, Falck JR, Garrett MR, Juncos LA, Roman RJ. Deficiency in the formation of 20-hydroxyeicosatetraenoic acid enhances renal ischemia-reperfusion injury. J Am Soc Nephrol. 2015; 26:2460-2469. PMCID: PMC4587700.
• O’Brien L, Hosick PA, John K, Stec DE, Hinds TD Jr. Biliverdin reductase isozymes in metabolism. Trends Endocrinol Metab. 2015; 26:212-220. PMCID: PMC4380527.
• Palei AC, Spradley FT, Granger JP. Chronic hyperleptinemia results in the development of hypertension in pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2015; 308:R855-R861.  PMCID: PMC4436978.
• Palei AC, Spradley FT, Granger JP. Role of nitric oxide on blood pressure regulation in pregnant rats on a high-fat diet (HFD). Pregnancy Hypertens. 2015;5(1):7.
• Ressler IB, Grayson BE, Ulrich-Lai YM, Seeley RJ. Diet-induced obesity exacerbates metabolic and behavioral effects of polycystic ovary syndrome in a rodent model. Am J Physiol Endocrinol Metab. 2015; 308:E1076-E1084. PMCID: PMC4469809.
• Sasser JM, Brinson KN, Tipton AJ, Crislip GR, Sullivan JC. Blood pressure, sex, and female sex hormones influence renal inner medullary nitric oxide synthase activity and expression in spontaneously hypertensive rats. J Am Heart Assoc. 2015; 10:4. PMCID: PMC4579936.
• Sasser JM, Murphy SR, Granger JP. Emerging drugs for preeclampsia-the endothelium as a target. Expert Opin Emerg Drugs. 2015; 20:527-530. PMCID: PMC4697827.
• Spires D, Taylor L, McPherson K, Williams JM. Effects of endothelin-A receptor and angiotensin converting enzyme inhibition on the development of progressive proteinuria in diabetic Dahl SS rats with pre-existing renal disease. FASEB J. 2015;29:959.8.
• Spradley FT, Palei AC, Granger JP. Immune Mechanisms Linking Obesity and Preeclampsia. Biomolecules. 2015; 5:3142-3176. PMCID: PMC4693273.
• Spradley FT, Palei AC, Granger JP. Increased risk for the development of preeclampsia in obese pregnancies: weighing in on the mechanisms. Am J Physiol Regul Integr Comp Physiol. 2015; 309:R1326-R1343. PMCID: PMC4698403.
• Tanner RM, Shimbo D, Dreisbach AW, Carson AP, Fox ER, Muntner P. Association between 24-hour blood pressure variability and chronic kidney disease: a cross-sectional analysis of African Americans participating in the Jackson heart study. BMC Nephrol. 2015; 16:84. PMCID: PMC4477603.
• Toba H, de Castro Brás LE, Baicu CF, Zile MR, Lindsey ML, Bradshaw AD. Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization. Am J Physiol Cell Physiol. 2015; 308:C972-C982. PMCID: PMC4469747.
• Tullos NA, Stewart NJ, Davidovich R, Chade AR. Chronic blockade of endothelin A and B receptors using macitentan in experimental renovascular disease. Nephrol Dial Transplant. 2015; 30:584-593. PMCID: PMC4370292.
• Voorhees AP, DeLeon-Pennell KY, Ma Y, Halade GV, Yabluchanskiy A, Iyer RP, Flynn E, Cates CA, Lindsey ML, Han HC. Building a better infarct: modulation of collagen cross-linking to increase infarct stiffness and reduce left ventricular dilation post-myocardial infarction. J Mol Cell Cardiol. 2015; 85:229-239. PMCID: PMC4530076.
• Wang L, Shen C, Liu H, Wang S, Chen X, Roman RJ, Juncos LA, Lu Y, Wei J, Zhang J, Yip KP, Liu R. Shear stress blunts tubuloglomerular feedback partially mediated by primary cilia and nitric oxide at the macula densa. Am J Physiol Regul Integr Comp Physiol. 2015; 309:R757-R766. PMCID: PMC4666931.
• Wang X, Johnson AC, Williams JM, White T, Chade AR, Zhang J, Liu R, Roman RJ, Lee JW, Kyle PB, Solberg-Woods L, Garrett MR. Nephron deficiency and predisposition to renal injury in a novel one-kidney genetic model. J Am Soc Nephrol. 2015; 26:1634-1646. PMCID: PMC4483580.
• Warrington JP. Placental ischemia increases seizure susceptibility and cerebrospinal fluid cytokines. Physiol Rep. 2015; 3. PMCID: PMC4673655.
• Warrington JP, Drummond HA, Granger JP, Ryan MJ. Placental ischemia-induced increases in brain water content and cerebrovascular permeability: role of TNF-α. Am J Physiol Regul Integr Comp Physiol. 2015; 309:R1425-R1431. PMCID: PMC4698405.
• Wu SP, Kao CY, Wang L, Creighton CJ, Yang J, Donti TR, Harmancey R, Vasquez HG, Graham BH, Bellen HJ, Taegtmeyer H, Chang CP, Tsai MJ, Tasi SY. Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure. Nat Commun. 2015;6:8245. PMCID: PMC4568566.
• Xiang L, Mittwede PN, Clemmer JS. Glucose homeostasis and cardiovascular alterations in diabetes. Compr Physiol. 2015; 5:1815-1839. PMID: 26426468.
• Yabluchanskiy A, Ma Y, Lindsey ML. Syndecan-4: a novel regulator of collagen synthesis and deposition in the pressure-overloaded myocardium. Cardiovasc Res. 2015; 106:178-179. PMID: 25808974.
• Yu B, Pulit SL, Hwang SJ, Brody JA, Amin N, Auer PL, Bis JC, Boerwinkle E, Burke GL, Chakravarti A, Correa A, Dreisbach AW, Franco OH, Ehret GB, Franceschini N, Hofman A, Lin DY, Metcalf GA, Musani SK, Muzny D, Palmas W, Raffel L, Reiner A, Rice K, Rotter JI, Veeraraghavan N, Fox E, Guo X, North KE, Gibbs RA, van Duijn CM, Psaty BM, Levy D, Newton-Cheh C, Morrison AC. Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium; National Heart, Lung, and Blood Institute GO Exome Sequencing Project. Rare Exome Sequence Variants in CLCN6 Reduce Blood Pressure Levels and Hypertension Risk. Circ Cardiovasc Genet. 2015; 9:64-70. PMCID: PMC4771070.